BIOLOGICAL DOMAIN

DNA & genome engineering

RM-C-04

DNA engineering reagents support sequence-specific cutting, end modification, ligation, assembly and genome editing workflows.

1301 products41 manufacturers13 branches

About DNA & genome engineering

Start with the change you want to make to DNA. Restriction digestion, ligation, assembly and end modification perform different steps, while genome editing introduces additional targeting requirements. Narrower categories distinguish enzyme identity, reaction role and formulation. A shared enzyme name alone does not establish matching cleavage behavior, buffer requirements or activity units.

Choose the required molecular activity before comparing substrate specificity, reaction conditions and supplied components.

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Research readiness

Candidate classification still requires protocol validation.

Beyotime

SaCas9 NLS

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Cas9 reagents / SaCas9 nucleases

Official manufacturer catalog lists this exact named enzyme and catalog code with a product-page hyperlink. Product-page body was unavailable due to a locale redirect; verify detailed conditions with the supplier. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.001.002.003-0002-2D0519S1 pack optionManufacturer link
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Takara Bio

SacI

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SacI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.320.003-0001-41078A1 pack optionManufacturer link
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Takara Bio

SacII

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SacII restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.321.001-0002-51079A1 pack optionManufacturer link
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Thermo Scientific

SalI

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SalI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.322.003-0005-3ER06411 pack optionManufacturer link
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SibEnzyme

SalI

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SalI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.322.003-0004-6See manufacturer1 pack optionManufacturer link
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Jena Bioscience

SalI

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SalI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.322.003-0001-2See manufacturer1 pack optionManufacturer link
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Takara Bio

SalI

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SalI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.322.003-0006-11080A1 pack optionManufacturer link
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Promega

SalI

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SalI restriction enzymes / Standard formulations

Official product page specifies the named restriction enzyme and catalog number. Classified as a standard formulation; verify recognition sequence, methylation sensitivity, temperature and recommended buffer. Confirm formulation, activity units and experimental conditions before substitution.

RM-04.013.322.003-0007-9R60511 pack optionManufacturer link
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Your selection checklist

  • 01Substrate specificity and intended application
  • 02Formulation, activity and concentration
  • 03Protocol conditions and required components
  • 04Pack size, storage and supplier documentation

ALTERNATIVE DOES NOT MEAN IDENTICAL

What to check before choosing a product

Final groups are designed around experimental substitution requirements. Group membership is provisional until the necessary technical details have been verified for the intended experiment.

Start with your application, then verify the technical requirements against each manufacturer’s documentation.

Explore manufacturer resources

Broader catalog resources for this branch. These links are discovery starting points, not verified replacements for individual products.