BIOLOGICAL DOMAIN

DNA & genome engineering

RM-C-04

DNA engineering reagents support sequence-specific cutting, end modification, ligation, assembly and genome editing workflows.

1301 products41 manufacturers13 branches

About DNA & genome engineering

Start with the change you want to make to DNA. Restriction digestion, ligation, assembly and end modification perform different steps, while genome editing introduces additional targeting requirements. Narrower categories distinguish enzyme identity, reaction role and formulation. A shared enzyme name alone does not establish matching cleavage behavior, buffer requirements or activity units.

Choose the required molecular activity before comparing substrate specificity, reaction conditions and supplied components.

Explore 13 narrower categories

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1,301 products
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Research readiness

Candidate classification still requires protocol validation.

Thermo Scientific

SmaI

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SmaI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.342.002-0004-4ER06611 pack optionManufacturer link
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SibEnzyme

SmaI

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SmaI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.342.002-0002-8See manufacturer1 pack optionManufacturer link
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Jena Bioscience

SmaI

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SmaI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.342.002-0001-0See manufacturer1 pack optionManufacturer link
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Takara Bio

SmaI

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SmaI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.342.002-0005-11085A1 pack optionManufacturer link
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Promega

SmaI

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SmaI restriction enzymes / Standard formulations

Official product page specifies the named restriction enzyme and catalog number. Classified as a standard formulation; verify recognition sequence, methylation sensitivity, temperature and recommended buffer. Confirm formulation, activity units and experimental conditions before substitution.

RM-04.013.342.002-0006-9R61211 pack optionManufacturer link
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SibEnzyme

SmaI Turbo

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SmaI restriction enzymes / Fast-digest formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.342.001-0001-2E177T/E178T1 pack optionManufacturer link
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Takara Bio

SmiI

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SmiI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.343.002-0001-91111A1 pack optionManufacturer link
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SibEnzyme

SmiI Turbo

Read or write a review

SmiI restriction enzymes / Fast-digest formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.343.001-0001-1E225T/E226T1 pack optionManufacturer link
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Jena Bioscience

SnaBI

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SnaBI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.345.001-0001-9See manufacturer1 pack optionManufacturer link
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Takara Bio

SnaBI

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SnaBI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.345.001-0004-31245A1 pack optionManufacturer link
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Beyotime

SNAP-dCas9

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Cas9 reagents / Inactive SpCas9 SNAP-tag fusion

Official manufacturer catalog lists this exact named enzyme and catalog code with a product-page hyperlink. Product-page body was unavailable due to a locale redirect; verify detailed conditions with the supplier. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.001.002.002-0002-4D0520S1 pack optionManufacturer link
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Takara Bio

SpeI

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SpeI restriction enzymes / Standard formulations

Manufacturer catalog identifies the named restriction enzyme and catalog code. Isoschizomer aliases are not treated as interchangeable products; check cleavage position, methylation sensitivity, temperature and buffer. Confirm the supplier protocol, formulation and activity units before substitution.

RM-04.013.346.002-0001-61086A1 pack optionManufacturer link
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Promega

SpeI

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SpeI restriction enzymes / Standard formulations

Official product page specifies the named restriction enzyme and catalog number. Classified as a standard formulation; verify recognition sequence, methylation sensitivity, temperature and recommended buffer. Confirm formulation, activity units and experimental conditions before substitution.

RM-04.013.346.002-0002-4R65911 pack optionManufacturer link
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SibEnzyme

SphI

Read or write a review

SphI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.347.002-0002-3See manufacturer1 pack optionManufacturer link
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Jena Bioscience

SphI

Read or write a review

SphI restriction enzymes / Standard formulations

Same enzyme identity candidate. Verify recognition and cleavage specificity, methylation sensitivity, reaction buffer, concentration and heat inactivation in the source before substitution.

RM-04.013.347.002-0001-5See manufacturer1 pack optionManufacturer link
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Showing 24 of 1301

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Your selection checklist

  • 01Substrate specificity and intended application
  • 02Formulation, activity and concentration
  • 03Protocol conditions and required components
  • 04Pack size, storage and supplier documentation

ALTERNATIVE DOES NOT MEAN IDENTICAL

What to check before choosing a product

Final groups are designed around experimental substitution requirements. Group membership is provisional until the necessary technical details have been verified for the intended experiment.

Start with your application, then verify the technical requirements against each manufacturer’s documentation.

Explore manufacturer resources

Broader catalog resources for this branch. These links are discovery starting points, not verified replacements for individual products.